CD276 antibody (AA 100-300)

Catalog No. ABIN7869823

The Mouse Monoclonal anti-CD276 antibody (Clone B7H3-4312) (ABIN7869823) specifically detects CD276 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CD276 antibody (AA 100-300) (ABIN7869823)

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: B7H3-4312

Product Details anti-CD276 Antibody

Binding Specificity: AA 100-300

Purpose: CD276 Antibody / B7-H3

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the CD276 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD276 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD276 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints