LHCGR antibody (AA 100-300)

Catalog No. ABIN7869843

The Mouse Monoclonal anti-LHCGR antibody is suitable to detect LHCGR in samples from Human. It has been validated for IHC (p).

Quick Overview for LHCGR antibody (AA 100-300) (ABIN7869843)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LHCGR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: LHCGR-7399

Product Details anti-LHCGR Antibody

Binding Specificity: AA 100-300

Purpose: Luteinizing Hormone Receptor Antibody / LH Receptor / hCG Receptor

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the Luteinizing Hormone Receptor antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Luteinizing Hormone Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Luteinizing Hormone Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Alternative Name: Luteinizing Hormone Receptor

Background: Recognizes a protein of 78-85 kDa, which is identified as Luteinizing hormone / choriogonadotropin receptor. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling