PKC iota antibody (AA 100-300)

Catalog No. ABIN7869854

This Mouse Monoclonal antibody specifically detects PKC iota in IHC (p). It exhibits reactivity toward Human.

Quick Overview for PKC iota antibody (AA 100-300) (ABIN7869854)

Target: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PKC iota antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: PRKCI-4911

Product Details anti-PKC iota Antibody

Binding Specificity: AA 100-300

Purpose: PRKCI Antibody / PKC iota (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 100-300 was used as the immunogen for the PRKCI antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the PRKCI antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the PRKCI antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PKC iota

Target: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Alternative Name: PRKCI

Background: Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes, including conventional (c) PKC isoforms (, , , l/i, m and n). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC i 1/2L and are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.

UniProt: P41743

Pathways: Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation