LY75/DEC-205 antibody (AA 1006-1130)

Catalog No. ABIN7869885

The Mouse Monoclonal anti-LY75/DEC-205 antibody is suitable to detect LY75/DEC-205 in samples from Human. It has been validated for IHC (p).

Quick Overview for LY75/DEC-205 antibody (AA 1006-1130) (ABIN7869885)

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LY75/DEC-205 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CD205-3720

Product Details anti-LY75/DEC-205 Antibody

Binding Specificity: AA 1006-1130

Purpose: LY75/DEC-205 Antibody / CD205

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1006-1130 was used as the immunogen for the LY75/DEC-205 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the LY75/DEC-205 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the LY75/DEC-205 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for LY75/DEC-205

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Alternative Name: LY75/DEC-205

Background: DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

UniProt: O60449