CBS antibody (AA 102-342)

Catalog No. ABIN7869914

This Mouse Monoclonal antibody specifically detects CBS in WB and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CBS antibody (AA 102-342) (ABIN7869914)

Target: CBS (Cystathionine-beta-Synthase (CBS))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBS antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 5B5D7

Product Details anti-CBS Antibody

Binding Specificity: AA 102-342

Purpose: CBS Antibody / Cystathionine Beta Synthase

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids K102-E342) was used as the immunogen for the CBS antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the CBS antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CBS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Alternative Name: CBS

Background: CBS, Cystathionine Beta-Synthase, catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity. The CBS gene, which is mapped to chromosome 21q22, contains 23 exons, ranging in size from 42 to 299 bp. The human CBS protein can substitute for the endogenous yeast CBS protein in Saccharomyces cerevisiae. The catalytic domain of the CBS protein is located in the N-terminal 409 amino acids, and a regulatory domain is located in the C-terminal 142 amino acids.A mutation that deletes the C-terminal 145 amino acids of CBS could restore activity of several CBS mutant alleles found in homocystinurics.

UniProt: P35520