CBS antibody (AA 102-342)

Catalog No. ABIN7869915

The Mouse Monoclonal anti-CBS antibody is suitable to detect CBS in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for CBS antibody (AA 102-342) (ABIN7869915)

Target: CBS (Cystathionine-beta-Synthase (CBS))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBS antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 7C3B7

Product Details anti-CBS Antibody

Binding Specificity: AA 102-342

Purpose: Cystathionine Beta Synthase Antibody / CBS

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids K102-E342) was used as the immunogen for the Cystathionine Beta Synthase antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Cystathionine Beta Synthase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Cystathionine Beta Synthase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Alternative Name: Cystathionine Beta Synthase

Background: CBS, Cystathionine Beta-Synthase, catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity. The CBS gene, which is mapped to chromosome 21q22, contains 23 exons, ranging in size from 42 to 299 bp. The human CBS protein can substitute for the endogenous yeast CBS protein in Saccharomyces cerevisiae. The catalytic domain of the CBS protein is located in the N-terminal 409 amino acids, and a regulatory domain is located in the C-terminal 142 amino acids.A mutation that deletes the C-terminal 145 amino acids of CBS could restore activity of several CBS mutant alleles found in homocystinurics.

UniProt: P35520