LLGL2 antibody (AA 102-553)

Catalog No. ABIN7869919

The Rabbit Polyclonal anti-LLGL2 antibody (ABIN7869919) specifically detects LLGL2 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for LLGL2 antibody (AA 102-553) (ABIN7869919)

Target: LLGL2 (Lethal Giant Larvae Homolog 2 (LLGL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LLGL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-LLGL2 Antibody

Binding Specificity: AA 102-553

Purpose: LLGL2 Antibody / Lethal giant larvae homolog 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human LLGL2 recombinant protein (Position: L102-Q553) was used as the immunogen for the LLGL2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LLGL2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LLGL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LLGL2

Target: LLGL2 (Lethal Giant Larvae Homolog 2 (LLGL2))

Alternative Name: LLGL2

Background: LLGL2 antibody detects Lethal giant larvae homolog 2, encoded by the LLGL2 gene. Lethal giant larvae homolog 2 is a cytoskeletal and polarity-associated protein that regulates cell polarity, asymmetric cell division, and epithelial organization. LLGL2 antibody provides researchers with a specific reagent for investigating epithelial biology, polarity regulation, and tumor progression.

Lethal giant larvae homolog 2 is a mammalian homolog of the Drosophila tumor suppressor lethal giant larvae, which was first identified as a critical determinant of apical-basal polarity. Research using LLGL2 antibody has demonstrated that LLGL2 contributes to the establishment and maintenance of polarity complexes by interacting with Scribble and Discs large proteins. These interactions ensure spatial organization of epithelial cells, maintaining tissue integrity and function.

Studies with LLGL2 antibody have revealed that it also regulates vesicle trafficking and exocytosis. LLGL2 interacts with SNARE proteins and the exocyst complex to control delivery of polarity proteins and growth factors to the plasma membrane. This vesicular trafficking role integrates with its polarity-regulating function, emphasizing its importance in epithelial biology.

Dysregulation of LLGL2 has been implicated in cancer. Research using LLGL2 antibody has shown that loss or reduction of LLGL2 expression correlates with disruption of cell polarity and increased invasiveness in breast and gastric cancers. Conversely, certain tumors exploit LLGL2 to promote growth factor recycling, supporting proliferation and survival. This dual role underscores the complexity of LLGL2 in tumor biology.

LLGL2 antibody is commonly used in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights reduced expression in cancer tissues, immunofluorescence demonstrates localization to the basolateral membrane, and western blotting quantifies expression across tissues. These approaches make LLGL2 antibody valuable for polarity and cancer research.

By supplying validated LLGL2 antibody reagents, NSJ Bioreagents supports studies into polarity regulation, epithelial biology, and tumorigenesis. Detection of Lethal giant larvae homolog 2 provides researchers with insight into how polarity proteins maintain tissue integrity and influence cancer progression.

UniProt: Q6P1M3

Pathways: WNT Signaling