SYNPO2 antibody (AA 104-1009)

Catalog No. ABIN7869935

This Rabbit Polyclonal antibody specifically detects SYNPO2 in ELISA, WB and FACS. It exhibits reactivity toward Human.

Quick Overview for SYNPO2 antibody (AA 104-1009) (ABIN7869935)

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNPO2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-SYNPO2 Antibody

Binding Specificity: AA 104-1009

Purpose: SYNPO2 Antibody / Synaptopodin 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SYNPO2 recombinant protein (Position: L104-R1009) was used as the immunogen for the SYNPO2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SYNPO2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SYNPO2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SYNPO2

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Alternative Name: SYNPO2

Background: SYNPO2 antibody detects Synaptopodin-2, encoded by the SYNPO2 gene on chromosome 4q26. SYNPO2 antibody is widely used in muscle biology, actin cytoskeleton research, and cancer studies. Synaptopodin-2 is an actin-associated protein highly expressed in muscle tissues, where it regulates cytoskeletal dynamics, sarcomere organization, and cellular migration. It is involved in stress fiber formation and focal adhesion assembly, contributing to cell shape and motility.

Structurally, Synaptopodin-2 is a large protein of ~118 kDa with multiple proline-rich motifs, actin-binding sites, and SH3-binding domains. It interacts with alpha-actinin, zyxin, and other cytoskeletal regulators. Alternative isoforms generated by splicing are expressed in specific tissues, providing diversity in cytoskeletal regulation. Synaptopodin-2 localizes to actin filaments, focal adhesions, and stress fibers.

Functionally, Synaptopodin-2 modulates actin filament bundling, focal adhesion dynamics, and muscle fiber organization. It is essential for maintaining sarcomere integrity and supports repair processes after muscle injury. Researchers use SYNPO2 antibody to investigate cytoskeletal dynamics, mechanotransduction, and muscle physiology.

Clinically, mutations in SYNPO2 have been linked to myopathy and other muscle disorders. Dysregulation of Synaptopodin-2 expression is associated with cancer progression, where it influences invasion and metastasis. Its actin-regulatory role positions it as a biomarker of cytoskeletal remodeling and tumor aggressiveness. NSJ Bioreagents provides SYNPO2 antibody for research in cytoskeleton biology, muscle pathology, and oncology.

Experimentally, SYNPO2 antibody is used in western blotting to detect the ~118 kDa protein, in immunofluorescence to visualize stress fiber association, and in immunohistochemistry to study expression in muscle and tumor tissues. Co-immunoprecipitation with SYNPO2 antibody identifies cytoskeletal partners including alpha-actinin and zyxin.

UniProt: Q9UMS6