GHDC antibody (AA 108-426)

Catalog No. ABIN7870031

This Rabbit Polyclonal antibody specifically detects GHDC in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for GHDC antibody (AA 108-426) (ABIN7870031)

Target: GHDC (GH3 Domain Containing (GHDC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GHDC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GHDC Antibody

Binding Specificity: AA 108-426

Purpose: GHDC Antibody / GH3 domain-containing protein

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GHDC recombinant protein (Position: E108-S426) was used as the immunogen for the GHDC antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GHDC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GHDC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GHDC

Target: GHDC (GH3 Domain Containing (GHDC))

Alternative Name: GHDC

Background: GHDC antibody detects GH3 domain-containing protein, encoded by the GHDC gene on chromosome 5q31.3. GHDC antibody is used in studies of protein-protein interactions, signaling pathways, and developmental biology. GHDC is a relatively uncharacterized protein thought to play roles in cellular signaling and scaffolding functions through its GH3 domain, which mediates interactions with other signaling proteins. Expression is observed in multiple tissues, including brain, liver, kidney, and immune cells, suggesting broad biological roles.

Structurally, GHDC contains a conserved GH3 domain, originally identified in proteins involved in signaling and cytoskeletal organization. The GH3 domain enables GHDC to act as an adaptor protein, linking signaling molecules within cellular pathways. The protein also contains coiled-coil motifs that may support oligomerization or interactions with structural proteins. These features position GHDC as a potential mediator of cytoskeletal and signaling regulation.

Functionally, GHDC is predicted to participate in cytoskeletal organization, vesicle trafficking, and intracellular signaling. While detailed functions are still under investigation, experimental data suggest GHDC influences processes such as cell migration, adhesion, and signal transduction. Knockdown or mutation may disrupt these pathways, although phenotypic outcomes are not yet well defined. Researchers apply GHDC antibody to explore the roles of novel domain-containing proteins and their integration into known signaling networks.

Clinically, GHDC remains underexplored, but variants have been identified in genetic screens of developmental disorders and neurological disease. Genome-wide association studies have linked GHDC locus variants to neuropsychiatric traits, though causality remains to be determined. Altered expression of GHDC has been observed in some cancers, hinting at roles in proliferation or migration. Ongoing research aims to define its contributions to disease. NSJ Bioreagents supplies GHDC antibody to support early-stage research on this uncharacterized protein.

Experimentally, GHDC antibody is used in western blotting to detect the ~90 kDa protein, in immunofluorescence microscopy to study localization, and in immunohistochemistry to assess tissue expression. Immunoprecipitation with GHDC antibody allows identification of potential binding partners and domain-mediated interactions.

UniProt: Q8N2G8