EDC4 antibody (AA 1082-1388)

Catalog No. ABIN7870039

The Rabbit Polyclonal anti-EDC4 antibody (ABIN7870039) specifically detects EDC4 in ELISA, WB, IF, IHC (p) and FACS. The antibody is reactive with Human samples.

Quick Overview for EDC4 antibody (AA 1082-1388) (ABIN7870039)

Target: EDC4 (Enhancer of mRNA Decapping 4 (EDC4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDC4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-EDC4 Antibody

Binding Specificity: AA 1082-1388

Purpose: EDC4 Antibody / Enhancer of mRNA-decapping protein 4

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids K1082-L1388) was used as the immunogen for the EDC4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the EDC4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the EDC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for EDC4

Target: EDC4 (Enhancer of mRNA Decapping 4 (EDC4))

Alternative Name: EDC4

Background: Enhancer of mRNA-decapping protein 4 is a protein that in humans is encoded by the EDC4 gene. Enhancer of mRNA decapping 4 (EDC4) was originally identified as the autoantigen Ge-1 from a Sjogren's syndrome patient later diagnosed with primary biliary cirrhosis. EDC4 (also known as HEDLS) was later identified as an essential component of cytoplasmic P-bodies responsible for mRNA decapping and degradation. Identified EDC4 protein is found as a pair of isoforms generated by alternative splicing and contains several WD domains and a putative nuclear localization signal. EDC4 co-localizes with other P-body decapping proteins such as DCP1A, DCP2 and GW182. Experimental evidence suggests that EDC4 may be involved in miRNA-mediated translation repression.

UniProt: Q6P2E9