Neurogranin antibody (AA 11-54)

Catalog No. ABIN7870089

The Rabbit Polyclonal anti-Neurogranin antibody is suitable to detect Neurogranin in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for Neurogranin antibody (AA 11-54) (ABIN7870089)

Target: Neurogranin (NRGN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurogranin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Neurogranin Antibody

Binding Specificity: AA 11-54

Purpose: NRGN Antibody / Neurogranin

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids K11-K54) was used as the immunogen for the NRGN antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NRGN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NRGN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Neurogranin

Target: Neurogranin (NRGN)

Alternative Name: NRGN

Background: Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

UniProt: Q92686