RAP1GAP antibody (AA 11-661)

Catalog No. ABIN7870090

The Rabbit Polyclonal anti-RAP1GAP antibody (ABIN7870090) specifically detects RAP1GAP in WB, ELISA, IF, FACS and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RAP1GAP antibody (AA 11-661) (ABIN7870090)

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAP1GAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RAP1GAP Antibody

Binding Specificity: AA 11-661

Purpose: RAP1GAP Antibody / Rap1 GTPase-activating protein 1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids D11-L661) was used as the immunogen for the RAP1GAP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RAP1GAP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RAP1GAP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RAP1GAP

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Alternative Name: RAP1GAP

Background: Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene. This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

UniProt: P47736