MMP13 antibody (AA 110-476)

Catalog No. ABIN7870102

The Rabbit Polyclonal anti-MMP13 antibody (ABIN7870102) specifically detects MMP13 in WB and IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for MMP13 antibody (AA 110-476) (ABIN7870102)

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MMP13 Antibody

Binding Specificity: AA 110-476

Purpose: Zebrafish Mmp13a Antibody / Interstitial collagenase

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Mmp13a recombinant protein (amino acids D110-K476) was used as the immunogen for the Zebrafish Mmp13a antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Mmp13a antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Mmp13a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Alternative Name: Mmp13a

Background: Matrix metalloproteinase 13a (Mmp13a) is a member of the matrix metalloproteinase (MMP) family, enzymes that degrade components of the extracellular matrix (ECM). In zebrafish (Danio rerio), Mmp13a plays a pivotal role in tissue remodeling, skeletal development, and regeneration by regulating collagen breakdown and ECM turnover.

Mmp13a is particularly important during craniofacial morphogenesis, bone formation, and fin regeneration, where precise ECM remodeling is essential for cell migration, differentiation, and structural reorganization. Its expression is tightly regulated by signaling pathways such as Wnt, FGF, and TGF-i², and it can be induced in response to injury or developmental cues.

Due to its functional conservation with mammalian MMP13, zebrafish Mmp13a serves as a valuable model for studying osteogenesis, fibrosis, wound healing, and ECM-related diseases, including arthritis and cancer metastasis. Its robust expression during regeneration also makes it a useful biomarker for studies of tissue repair and regenerative biology.

UniProt: F1QCX8