STRBP antibody (AA 110-617)

Catalog No. ABIN7870104

The Rabbit Polyclonal anti-STRBP antibody is suitable to detect STRBP in samples from Human, Rat and Mouse. It has been validated for ELISA, WB, IF, IHC, ICC and FACS.

Quick Overview for STRBP antibody (AA 110-617) (ABIN7870104)

Target: STRBP (Spermatid Perinuclear RNA Binding Protein (STRBP))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRBP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-STRBP Antibody

Binding Specificity: AA 110-617

Purpose: STRBP Antibody / Spermatid perinuclear RNA-binding protein

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STRBP recombinant protein (Position: K110-R617) was used as the immunogen for the STRBP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STRBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STRBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STRBP

Target: STRBP (Spermatid Perinuclear RNA Binding Protein (STRBP))

Alternative Name: STRBP

Background: The STRBP antibody targets Spermatid perinuclear RNA-binding protein, a multifunctional RNA- and microtubule-associated protein encoded by the STRBP gene. Spermatid perinuclear RNA-binding protein is involved in RNA transport, post-transcriptional regulation, and microtubule organization. It contributes to spermatogenesis, neuronal differentiation, and stress granule assembly. The STRBP antibody provides researchers with a versatile reagent for investigating RNA-binding protein networks and cytoskeletal coordination during differentiation and stress responses.

Spermatid perinuclear RNA-binding protein contains multiple double-stranded RNA-binding motifs (dsRBDs) and a leucine zipper domain that mediate RNA recognition and dimerization. It localizes to the cytoplasm and perinuclear region, where it associates with RNA granules and microtubules. The STRBP antibody supports detection of this localization, enabling studies of its role in mRNA transport and translational control. STRBP is particularly enriched in developing spermatids, where it participates in the storage and regulation of mRNAs required for sperm maturation.

Beyond reproductive function, Spermatid perinuclear RNA-binding protein is expressed in multiple tissues, including brain and heart, where it modulates RNA metabolism and cytoskeletal integrity. It binds to microtubule-associated complexes to stabilize RNA localization during cellular polarization. The STRBP antibody enables visualization of these interactions, providing insight into how STRBP integrates RNA processing with cytoskeletal rearrangement in differentiating cells.

STRBP also plays a role in stress granule formation during cellular stress, interacting with proteins such as Staufen and DDX3X to regulate mRNA triage and translation repression. The STRBP antibody supports studies of these dynamic processes, helping to elucidate the molecular mechanisms underlying mRNA storage and recovery following stress exposure. Dysregulation of STRBP has been linked to infertility, neurodevelopmental disorders, and altered stress responses.

The STRBP antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, producing strong cytoplasmic and perinuclear staining consistent with its RNA granule localization. NSJ Bioreagents provides this antibody as a high-specificity reagent for reliable detection across molecular and cell biology studies. By supporting analysis of Spermatid perinuclear RNA-binding protein expression and function, the STRBP antibody advances understanding of RNA transport, cytoskeletal organization, and gene expression regulation in diverse biological contexts.

UniProt: Q96SI9