HOXB2 antibody (AA 114-220)

Catalog No. ABIN7870168

The Mouse Monoclonal anti-HOXB2 antibody (Clone PCRP-HOXB2-1F2) (ABIN7870168) specifically detects HOXB2 in WB, ELISA, IF, IHC (p) and FACS. The antibody is reactive with Human samples.

Quick Overview for HOXB2 antibody (AA 114-220) (ABIN7870168)

Target: HOXB2 (Homeobox B2 (HOXB2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HOXB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: PCRP-HOXB2-1F2

Product Details anti-HOXB2 Antibody

Binding Specificity: AA 114-220

Purpose: HOXB2 Antibody

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 114-220 was used as the immunogen for the HOXB2 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the HOXB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the HOXB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for HOXB2

Target: HOXB2 (Homeobox B2 (HOXB2))

Alternative Name: HOXB2

Background: Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene HoxB1 is critical to hindbrain development and has phenotypic features frequently observed in autism. Analysis of expression and targeted disruption of HoxB1 demonstrates that it is also essential for patterning progenitor cells along the entire DV axis of rhombomere 4 (r4). HoxB1 maintains this function by acting very early during hindbrain neurogenesis to specify effectors of the Sonic hedgehog and Mash1 signaling pathways. HoxB2 is a homeodomain protein important in neural development that is also expressed during erythropoiesis, hindbrain development and normal human adult lung development. HoxB2 may modulate the amount of gamma-globin mRNA expressed during development and differentiation. In addition, HoxB2 plays an important role in the patterning of hindbrain and pharyngeal arches in the zebrafish.

UniProt: P14652