Dystrophin antibody (AA 114-263)

Catalog No. ABIN7870180

The Mouse Monoclonal anti-Dystrophin antibody (Clone DSTN-1) (ABIN7870180) specifically detects Dystrophin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Dystrophin antibody (AA 114-263) (ABIN7870180)

Target: Dystrophin (DMD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Dystrophin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DSTN-1

Product Details anti-Dystrophin Antibody

Binding Specificity: AA 114-263

Purpose: Dystrophin Antibody / DMD

Purification: Protein G affinity chromatography

Immunogen: Amino acids 114-263 from the human protein were used as the immunogen for the Dystrophin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Dystrophin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Dystrophin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Dystrophin

Target: Dystrophin (DMD)

Alternative Name: Dystrophin

Background: The DMD gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [RefSeq]

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development