TPSAB1 antibody (AA 115-233)

Catalog No. ABIN7870206

The Mouse Monoclonal anti-TPSAB1 antibody is suitable to detect TPSAB1 in samples from Human. It has been validated for IHC (p).

Quick Overview for TPSAB1 antibody (AA 115-233) (ABIN7870206)

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TPSAB1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPSAB1-1961

Product Details anti-TPSAB1 Antibody

Binding Specificity: AA 115-233

Purpose: TPSAB1 Antibody / Mast Cell Tryptase

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 115-233 from the human protein was used as the immunogen for this TPSAB1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the TPSAB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the TPSAB1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TPSAB1

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Alternative Name: TPSAB1

Background: Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

UniProt: Q15661