PCDHa8 antibody (AA 118-801)

Catalog No. ABIN7870268

This Rabbit Polyclonal antibody specifically detects PCDHa8 in WB, ELISA and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for PCDHa8 antibody (AA 118-801) (ABIN7870268)

Target: PCDHa8 (Protocadherin alpha 8 (PCDHa8))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHa8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PCDHa8 Antibody

Binding Specificity: AA 118-801

Purpose: PCDHA8 Antibody / Protocadherin alpha-8

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids H118-Q801) was used as the immunogen for the PCDHA8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PCDHA8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PCDHA8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PCDHa8

Target: PCDHa8 (Protocadherin alpha 8 (PCDHa8))

Alternative Name: PCDHA8

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

UniProt: Q9Y5H6