MECP2 antibody (AA 119-453)

Catalog No. ABIN7870278

The Mouse Monoclonal anti-MECP2 antibody is suitable to detect MECP2 in samples from Human. It has been validated for WB.

Quick Overview for MECP2 antibody (AA 119-453) (ABIN7870278)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MECP2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 2G3

Product Details anti-MECP2 Antibody

Binding Specificity: AA 119-453

Purpose: MECP2 Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids K119-R453) was used as the immunogen for the MECP2 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the MECP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MECP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Alternative Name: MECP2

Background: MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane