PFKFB1 antibody (AA 12-186)

Catalog No. ABIN7870283

This Rabbit Polyclonal antibody specifically detects PFKFB1 in WB, ELISA, IHC (p) and FACS. It exhibits reactivity toward Human.

Quick Overview for PFKFB1 antibody (AA 12-186) (ABIN7870283)

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKFB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-PFKFB1 Antibody

Binding Specificity: AA 12-186

Purpose: PFKFB1 Antibody / Fructose-2,6-bisphosphatase

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids R12-R186) was used as the immunogen for the PFKFB1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PFKFB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PFKFB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PFKFB1

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Alternative Name: PFKFB1

Background: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

UniProt: P16118

Pathways: Regulation of Carbohydrate Metabolic Process