STRADA antibody (AA 12-41)

Catalog No. ABIN7870293

The Rabbit Polyclonal anti-STRADA antibody is suitable to detect STRADA in samples from Human. It has been validated for WB, IF and FACS.

Quick Overview for STRADA antibody (AA 12-41) (ABIN7870293)

Target: STRADA (STE20-Related Kinase Adaptor alpha (STRADA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRADA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-STRADA Antibody

Binding Specificity: AA 12-41

Purpose: LYK5 Antibody / STRADA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 12-41 from the human protein was used as the immunogen for the LYK5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the LYK5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the LYK5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for STRADA

Target: STRADA (STE20-Related Kinase Adaptor alpha (STRADA))

Alternative Name: LYK5

Background: LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.

UniProt: Q7RTN6

Pathways: AMPK Signaling