Sclerostin antibody (AA 12-42)

Catalog No. ABIN7870294

The Rabbit Polyclonal anti-Sclerostin antibody (ABIN7870294) specifically detects Sclerostin in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Sclerostin antibody (AA 12-42) (ABIN7870294)

Target: Sclerostin (SOST)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sclerostin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Sclerostin Antibody

Binding Specificity: AA 12-42

Purpose: Sclerostin Antibody / SOST

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 12-42 from the human protein was used as the immunogen for the Sclerostin antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Sclerostin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Sclerostin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Sclerostin

Target: Sclerostin (SOST)

Alternative Name: Sclerostin

Background: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

UniProt: Q9BQB4