HDC antibody (AA 12-662)

Catalog No. ABIN7870302

The Rabbit Polyclonal anti-HDC antibody is suitable to detect HDC in samples from Human and Mouse. It has been validated for WB, ELISA and IHC (p).

Quick Overview for HDC antibody (AA 12-662) (ABIN7870302)

Target: HDC (Histidine Decarboxylase (HDC))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HDC Antibody

Binding Specificity: AA 12-662

Purpose: Histidine decarboxylase Antibody / HDC

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R12-V662) was used as the immunogen for the Histidine decarboxylase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Histidine decarboxylase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Histidine decarboxylase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HDC

Target: HDC (Histidine Decarboxylase (HDC))

Alternative Name: Histidine decarboxylase

Background: HDC (Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

UniProt: P19113