MBD2 antibody (AA 120-152)

Catalog No. ABIN7870307

This Rabbit Polyclonal antibody specifically detects MBD2 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for MBD2 antibody (AA 120-152) (ABIN7870307)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MBD2 Antibody

Binding Specificity: AA 120-152

Purpose: MBD2 Antibody / Methyl-CpG-binding domain protein 2

Purification: Antigen affinity

Immunogen: A portion of amino acids 120-152 from the human protein was used as the immunogen for the MBD2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the MBD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MBD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Alternative Name: MBD2

Background: MBD2 is part of a family of proteins that possess a methyl-CpG-binding domain, allowing them to recognize and bind to DNA that has been modified by the addition of methyl groups. This binding has important implications for gene expression, as methylation can either activate or repress gene transcription. One of the most intriguing aspects of MBD2 is its ability to recruit other proteins to the methylated DNA, influencing the chromatin structure and ultimately determining whether a particular gene is switched on or off. This dynamic interplay between MBD2 and other regulatory proteins highlights the complexity of epigenetic regulation. Research into MBD2 has uncovered its involvement in a wide range of biological processes, from embryonic development to cancer progression. Dysregulation of MBD2 has been linked to aberrant gene expression patterns seen in various diseases, making it a potential target for therapeutic interventions.

Pathways: Chromatin Binding