Utrophin antibody (AA 1211-2294)

Catalog No. ABIN7870323

The Rabbit Polyclonal anti-Utrophin antibody is suitable to detect Utrophin in samples from Human and Mouse. It has been validated for WB, ELISA and IF.

Quick Overview for Utrophin antibody (AA 1211-2294) (ABIN7870323)

Target: Utrophin (UTRN)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Utrophin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Utrophin Antibody

Binding Specificity: AA 1211-2294

Purpose: Utrophin Antibody / UTRN

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids L1211-K2294) was used as the immunogen for the Utrophin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Utrophin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Utrophin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Utrophin

Target: Utrophin (UTRN)

Alternative Name: Utrophin

Background: Utrophin is a protein that in humans is encoded by the UTRN gene. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described, however, the full-length nature of these variants has not yet been determined.

UniProt: P46939

Pathways: Skeletal Muscle Fiber Development