RNF20 antibody (AA 123-389)

Catalog No. ABIN7870352

This Mouse Monoclonal antibody specifically detects RNF20 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RNF20 antibody (AA 123-389) (ABIN7870352)

Target: RNF20 (Ring Finger Protein 20 (RNF20))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This RNF20 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3C6E2

Product Details anti-RNF20 Antibody

Binding Specificity: AA 123-389

Purpose: RNF20 Antibody / BRE1A

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E123-S389) was used as the immunogen for the RNF20 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the RNF20 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RNF20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RNF20

Target: RNF20 (Ring Finger Protein 20 (RNF20))

Alternative Name: RNF20

Background: E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).

UniProt: Q5VTR2