BACE1 antibody (AA 125-154)

Catalog No. ABIN7870373

This Rabbit Polyclonal antibody specifically detects BACE1 in WB, IHC (p) and FACS. It exhibits reactivity toward Human.

Quick Overview for BACE1 antibody (AA 125-154) (ABIN7870373)

Target: BACE1 (Beta-secretase 1 (BACE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BACE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-BACE1 Antibody

Binding Specificity: AA 125-154

Purpose: Beta-secretase 1 Antibody / Memapsin-2 / BACE1C

Purification: Purified

Immunogen: A portion of amino acids 125-154 from the human protein was used as the immunogen for the Beta-secretase 1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Beta-secretase 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Beta-secretase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for BACE1

Target: BACE1 (Beta-secretase 1 (BACE1))

Alternative Name: Beta-secretase 1

Background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the BACE1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.

UniProt: P56817