MECOM antibody (AA 125-743)

Catalog No. ABIN7870380

The Rabbit Polyclonal anti-MECOM antibody is suitable to detect MECOM in samples from Human. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for MECOM antibody (AA 125-743) (ABIN7870380)

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MECOM antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-MECOM Antibody

Binding Specificity: AA 125-743

Purpose: PRDM3 Antibody / MECOM / EVI1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E125-D743) was used as the immunogen for the PRDM3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PRDM3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PRDM3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MECOM

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Alternative Name: PRDM3

Background: MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

UniProt: Q03112