PLAUR antibody (AA 128-167)

Catalog No. ABIN7870411

The Rabbit Polyclonal anti-PLAUR antibody (ABIN7870411) specifically detects PLAUR in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for PLAUR antibody (AA 128-167) (ABIN7870411)

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAUR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PLAUR Antibody

Binding Specificity: AA 128-167

Purpose: PLAUR Antibody / uPAR / uPA Receptor

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E128-R167) was used as the immunogen for the PLAUR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PLAUR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PLAUR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PLAUR

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Alternative Name: PLAUR

Background: PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

UniProt: Q03405

Pathways: Inositol Metabolic Process