TOP3B antibody (AA 128-824)

Catalog No. ABIN7870416

The Rabbit Polyclonal anti-TOP3B antibody is suitable to detect TOP3B in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC (p).

Quick Overview for TOP3B antibody (AA 128-824) (ABIN7870416)

Target: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOP3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TOP3B Antibody

Binding Specificity: AA 128-824

Purpose: TOP3B Antibody / DNA topoisomerase 3-beta-1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E128-R824) was used as the immunogen for the TOP3B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TOP3B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TOP3B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TOP3B

Target: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Alternative Name: TOP3B

Background: DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

UniProt: O95985