STIL antibody (AA 13-1287)

Catalog No. ABIN7870455

The Rabbit Polyclonal anti-STIL antibody is suitable to detect STIL in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC (p) and FACS.

Quick Overview for STIL antibody (AA 13-1287) (ABIN7870455)

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-STIL Antibody

Binding Specificity: AA 13-1287

Purpose: STIL Antibody / SIL / SCL-interrupting locus protein

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N13-F1287) was used as the immunogen for the STIL antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STIL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STIL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STIL

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Alternative Name: STIL

Background: SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene. This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q15468

Pathways: Tube Formation