IL-31 antibody (AA 13-40)

Catalog No. ABIN7870473

The Rabbit Polyclonal anti-IL-31 antibody is suitable to detect IL-31 in samples from Human. It has been validated for WB, IHC (p) and FACS.

Quick Overview for IL-31 antibody (AA 13-40) (ABIN7870473)

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-31 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-IL-31 Antibody

Binding Specificity: AA 13-40

Purpose: IL-31 Antibody / Interleukin 31

Purification: Antigen affinity

Immunogen: A portion of amino acids 13-40 from the human protein was used as the immunogen for the IL-31 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the IL-31 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL-31 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Alternative Name: IL-31

Background: Interleukin 31 (IL-31) is a cytokine that plays a critical role in inflammatory responses and allergic reactions in the body. IL-31 is produced by T-helper 2 (Th2) cells, which are involved in the body's response to allergens and parasites. When released, IL-31 binds to receptors on various cells in the body, triggering a cascade of inflammatory responses that can lead to symptoms such as itching, redness, and swelling. Studies have shown that IL-31 is particularly important in the development of atopic dermatitis, a common skin condition characterized by itchy, inflamed skin. In individuals with atopic dermatitis, levels of IL-31 are often elevated in the skin, leading to increased inflammation and itching. Additionally, IL-31 has also been implicated in other inflammatory conditions such as asthma and inflammatory bowel disease, highlighting its importance in the body's immune response.

UniProt: Q6EBC2