Erythrocyte Ankyrin antibody (AA 1300-1844)

Catalog No. ABIN7870500

The Mouse Monoclonal anti-Erythrocyte Ankyrin antibody is suitable to detect Erythrocyte Ankyrin in samples from Human. It has been validated for WB.

Quick Overview for Erythrocyte Ankyrin antibody (AA 1300-1844) (ABIN7870500)

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Erythrocyte Ankyrin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 9I6C3

Product Details anti-Erythrocyte Ankyrin Antibody

Binding Specificity: AA 1300-1844

Purpose: Ankyrin-1 Antibody / ANK1 / Erythrocyte

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N1300-Q1844) was used as the immunogen for the Ankyrin-1 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the Ankyrin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Ankyrin-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Erythrocyte Ankyrin

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Alternative Name: Ankyrin-1

Background: Ankyrin 1, erythrocytic, also known as ANK1, is a protein that in humans is encoded by the ANK1 gene. Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats, a central region with a highly conserved spectrin binding domain, and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

UniProt: P16157

Pathways: Synaptic Membrane