Seryl-tRNA Synthetase (SARS) (AA 133-483) antibody

Catalog No. ABIN7870526

This Rabbit Polyclonal antibody specifically detects Seryl-tRNA Synthetase in WB and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for Seryl-tRNA Synthetase (SARS) (AA 133-483) antibody (ABIN7870526)

Target: Seryl-tRNA Synthetase (SARS)

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 133-483

Purpose: Zebrafish Sars1 Antibody / Serine-tRNA ligase / SerRS

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Sars1 recombinant protein (amino acids R133-K483) was used as the immunogen for the Zebrafish Sars1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Sars1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Sars1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: Seryl-tRNA Synthetase (SARS)

Alternative Name: Sars1

Background: Zebrafish Sars1, also known as serine tRNA ligase, is an essential enzyme involved in protein synthesis. It belongs to the class of aminoacyl tRNA synthetases, which are responsible for attaching specific amino acids to their corresponding tRNAs during translation. Sars1 specifically catalyzes the attachment of the amino acid serine to its cognate tRNA, a critical step in the elongation of polypeptides during ribosomal protein synthesis. This activity ensures that serine is accurately incorporated into nascent proteins, which is fundamental for proper cellular function and growth.

Zebrafish Sars1 is an ortholog of the human SARS1 protein, with strong sequence conservation and functional similarity between the two species. In both zebrafish and humans, Sars1 plays an important role not only in protein translation but also in maintaining cellular homeostasis and regulating developmental processes that require high rates of protein synthesis. Zebrafish models have proven to be effective for studying Sars1 because of their genetic similarity to humans and the ability to observe its function in early embryonic development.

Currently, there is no evidence of multiple isoforms of zebrafish Sars1, but like many aminoacyl tRNA synthetases, it may have additional roles beyond translation, such as participation in signaling pathways and stress responses. Studies using antibodies against zebrafish Sars1 protein can provide insights into the regulation of translation and its connections to cellular pathways.

Antibodies targeting zebrafish Sars1 are valuable tools for research in protein synthesis, developmental biology, and molecular genetics. Because of its orthology with human SARS1, zebrafish Sars1 serves as a relevant model for studying conserved aspects of translational control and related diseases.

UniProt: Q6DRC0