PA2G4 antibody (AA 137-177)

Catalog No. ABIN7870567

The Rabbit Polyclonal anti-PA2G4 antibody (ABIN7870567) specifically detects PA2G4 in IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for PA2G4 antibody (AA 137-177) (ABIN7870567)

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PA2G4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PA2G4 Antibody

Binding Specificity: AA 137-177

Purpose: Zebrafish Pa2g4 Antibody / Pa2g4a / Pa2g4b

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Pa2g4 recombinant protein (amino acids R137-K177) was used as the immunogen for the Zebrafish Pa2g4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Pa2g4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Pa2g4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PA2G4

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Alternative Name: Pa2g4

Background: Proliferation-associated 2G4, also known as Pa2g4, is a key protein involved in regulating several fundamental cellular processes, including cell cycle progression, apoptosis, and transcriptional regulation. It is a member of the pentraxin family of proteins, which are important in immune modulation and inflammatory responses. Pa2g4 functions to ensure the proper regulation of cell survival and proliferation, particularly during embryonic development and under cellular stress conditions.

In zebrafish, Pa2g4 is an ortholog of the human PA2G4 gene. Both zebrafish and human Pa2g4 proteins share conserved functional domains, including the pentraxin domain, which is involved in protein-protein interactions and modulation of inflammatory signaling pathways. The functional similarity between the zebrafish and human versions of Pa2g4 makes the zebrafish model particularly useful for studying the roles of Pa2g4 in cellular growth, immune responses, and disease modeling.

In addition to its role in regulating the cell cycle, Pa2g4 is involved in the stress response by influencing pathways that govern cell survival and apoptosis. Pa2g4 interacts with various cell cycle regulators such as cyclins and cyclin-dependent kinases to modulate cell cycle progression and ensure proper timing of cellular events. Moreover, Pa2g4 is essential in immune cell function by regulating the activation and proliferation of immune cells during inflammatory conditions.

Pa2g4 is expressed in several tissues in zebrafish, including the brain, heart, and liver, and plays a crucial role during early embryogenesis. It is involved in developmental processes such as neurogenesis, organogenesis, and cell differentiation. Pa2g4 is also important for maintaining tissue homeostasis, and its regulation ensures normal tissue repair and regenerative processes.

Because of its evolutionary conservation and involvement in key biological pathways, zebrafish Pa2g4 is a valuable model for studying developmental biology, cancer research, immunology, and cell cycle regulation.

UniProt: Q8AW82

Pathways: Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades