HAS2 antibody (AA 138-166)

Catalog No. ABIN7870582

The Rabbit Polyclonal anti-HAS2 antibody (ABIN7870582) specifically detects HAS2 in WB, FACS and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for HAS2 antibody (AA 138-166) (ABIN7870582)

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAS2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HAS2 Antibody

Binding Specificity: AA 138-166

Purpose: Hyaluronan synthase 2 Antibody / HAS2

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 138-166 from the human protein was used as the immunogen for the Hyaluronan synthase 2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Hyaluronan synthase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Hyaluronan synthase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Alternative Name: Hyaluronan synthase 2

Background: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process