KNG1 antibody (AA 138-166)

Catalog No. ABIN7870583

This Rabbit Polyclonal antibody specifically detects KNG1 in WB, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for KNG1 antibody (AA 138-166) (ABIN7870583)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KNG1 Antibody

Binding Specificity: AA 138-166

Purpose: KNG1 Antibody / Kininogen 1 / Bradykinin

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 138-166 from the human protein was used as the immunogen for the KNG1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the KNG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the KNG1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process