PRDM8 antibody (AA 14-405)

Catalog No. ABIN7870635

The Rabbit Polyclonal anti-PRDM8 antibody is suitable to detect PRDM8 in samples from Human. It has been validated for WB, ELISA and IF.

Quick Overview for PRDM8 antibody (AA 14-405) (ABIN7870635)

Target: PRDM8 (PR Domain Containing 8 (PRDM8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-PRDM8 Antibody

Binding Specificity: AA 14-405

Purpose: PRDM8 Antibody / PR domain zinc finger protein 8

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids D14-D405) was used as the immunogen for the PRDM8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PRDM8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PRDM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PRDM8

Target: PRDM8 (PR Domain Containing 8 (PRDM8))

Alternative Name: PRDM8

Background: PRDM8 antibody targets PR domain zinc finger protein 8, encoded by the PRDM8 gene. PRDM8 is a member of the PRDM family of transcriptional regulators characterized by the presence of a PR domain related to SET methyltransferase domains and multiple C2H2-type zinc finger motifs. Proteins in this family function primarily as regulators of gene expression and chromatin state, linking sequence-specific DNA binding to epigenetic control mechanisms. PRDM8 is predominantly localized in the nucleus, where it associates with chromatin and transcriptional complexes to modulate gene regulatory programs.

Functionally, PRDM8 acts as a transcriptional regulator involved in developmental patterning and cell fate determination. Although the PR domain in some PRDM family members lacks intrinsic enzymatic activity, PRDM8 can recruit chromatin-modifying enzymes such as histone methyltransferases or deacetylases to target loci. Through these interactions, PRDM8 contributes to the establishment and maintenance of transcriptional repression or activation states, depending on cellular context. A PRDM8 antibody supports studies focused on transcriptional control, chromatin organization, and epigenetic regulation.

PRDM8 expression is enriched in the nervous system, where it has been implicated in neuronal differentiation, circuit formation, and regional specification during development. Studies have shown that PRDM8 participates in defining neuronal identity by regulating gene expression programs required for maturation and connectivity. In adult tissues, PRDM8 expression is more restricted but remains detectable in brain and selected cell types, reflecting its specialized regulatory roles. Cell-type-specific expression patterns underscore the importance of PRDM8 in tightly controlled developmental and differentiation processes.

From a disease-relevance perspective, PRDM8 has been investigated in the context of neurodevelopmental disorders and cancer biology. Dysregulation of PRDM family proteins can disrupt normal epigenetic control and transcriptional balance, contributing to aberrant cell proliferation or differentiation. Altered PRDM8 expression has been reported in certain tumor types, where changes in chromatin regulation may support malignant transformation or progression. These findings have positioned PRDM8 as a molecule of interest in studies of epigenetic dysregulation and disease-associated transcriptional remodeling.

At the molecular level, PRDM8 contains multiple zinc finger domains that enable sequence-specific DNA binding and protein-protein interactions. Isoform diversity, post-translational modifications, and interaction with chromatin-associated factors can influence its regulatory activity and electrophoretic behavior on SDS-PAGE without implying changes in primary sequence. A PRDM8 antibody supports research applications focused on nuclear protein expression, transcriptional regulation, and disease-associated changes in epigenetic control, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9NQV8