PRDM8 antibody (AA 14-405)

Catalog No. ABIN7870635

The Rabbit Polyclonal anti-PRDM8 antibody is suitable to detect PRDM8 in samples from Human. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for PRDM8 antibody (AA 14-405) (ABIN7870635)

Target: PRDM8 (PR Domain Containing 8 (PRDM8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PRDM8 Antibody

Binding Specificity: AA 14-405

Purpose: PRDM8 Antibody / PR domain zinc finger protein 8

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids D14-D405) was used as the immunogen for the PRDM8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PRDM8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PRDM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PRDM8

Target: PRDM8 (PR Domain Containing 8 (PRDM8))

Alternative Name: PRDM8

Background: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants.

UniProt: Q9NQV8