DNASE1L3 antibody (AA 14-43)

Catalog No. ABIN7870640

This Rabbit Polyclonal antibody specifically detects DNASE1L3 in WB. It exhibits reactivity toward Rat.

Quick Overview for DNASE1L3 antibody (AA 14-43) (ABIN7870640)

Target: DNASE1L3 (Deoxyribonuclease I-Like 3 (DNASE1L3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNASE1L3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DNASE1L3 Antibody

Binding Specificity: AA 14-43

Purpose: DNASE1L3 Antibody / Deoxyribonuclease gamma

Purification: Antigen affinity

Immunogen: A portion of amino acids 14-43 from the human protein was used as the immunogen for this DNASE1L3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the DNASE1L3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4oC for up to one month. For long term, aliquot the DNASE1L3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DNASE1L3

Target: DNASE1L3 (Deoxyribonuclease I-Like 3 (DNASE1L3))

Alternative Name: DNASE1L3

Background: DNASE1L3 is a member of the deoxyribonuclease enzyme family, responsible for breaking down DNA molecules into smaller fragments. This process is essential for the clearance of cellular debris, including dying cells and extracellular DNA released during inflammation. Without the action of DNASE1L3, the accumulation of DNA waste can lead to autoimmune diseases and other inflammatory conditions. Research has shown that DNASE1L3 plays a key role in modulating immune responses and protecting against inflammatory damage. By efficiently clearing DNA debris, this enzyme helps to maintain the balance between immunity and tolerance in the body. Dysregulation of DNASE1L3 activity has been linked to various autoimmune disorders, highlighting the importance of this enzyme in immune homeostasis. Furthermore, DNASE1L3 has been identified as a potential therapeutic target for treating autoimmune diseases and inflammatory conditions. By enhancing the activity of this enzyme, researchers hope to restore immune balance and prevent the development of autoimmune reactions.

UniProt: Q13609