SOX3 antibody (AA 141-285)

Catalog No. ABIN7870673

This Rabbit Polyclonal antibody specifically detects SOX3 in WB. It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for SOX3 antibody (AA 141-285) (ABIN7870673)

Target: SOX3 (SRY (Sex Determining Region Y)-Box 3 (SOX3))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SOX3 Antibody

Binding Specificity: AA 141-285

Purpose: Zebrafish Sox3 Antibody / SRY-box 3

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Sox3 recombinant protein (amino acids Q141-Q285) was used as the immunogen for the Zebrafish Sox3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Sox3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Sox3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SOX3

Target: SOX3 (SRY (Sex Determining Region Y)-Box 3 (SOX3))

Alternative Name: Sox3

Background: SRY-box transcription factor 3 (Sox3) is a member of the SoxB1 subfamily of transcription factors, which are key regulators of early embryonic development and neural differentiation. In zebrafish (Danio rerio), Sox3 plays a critical role in the formation of the nervous system, maintenance of neural progenitor identity, and early ectodermal patterning.

Sox3 is maternally deposited and is expressed in the neuroectoderm during early development. It acts as a transcriptional activator that promotes neural fate by regulating genes involved in progenitor cell maintenance and inhibiting premature neuronal differentiation. Sox3 also contributes to the development of the pituitary gland, sensory placodes, and hypothalamic structures.

Due to its conservation across vertebrates, zebrafish Sox3 serves as a powerful model for studying neurogenesis, pluripotency, and transcriptional regulation during early embryonic development. It is also used to investigate mechanisms of cell fate decisions, stem cell biology, and congenital neurological disorders.

UniProt: Q6EJB7