IPO7 antibody (AA 142-169)

Catalog No. ABIN7870679

This Rabbit Polyclonal antibody specifically detects IPO7 in WB and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for IPO7 antibody (AA 142-169) (ABIN7870679)

Target: IPO7 (Importin 7 (IPO7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IPO7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IPO7 Antibody

Binding Specificity: AA 142-169

Purpose: IPO7 Antibody / Importin 7

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 142-169 from the human protein was used as the immunogen for the IPO7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the IPO7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IPO7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IPO7

Target: IPO7 (Importin 7 (IPO7))

Alternative Name: IPO7

Background: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

UniProt: O95373

Pathways: Protein targeting to Nucleus