WDR26 antibody (AA 142-583)

Catalog No. ABIN7870693

The Rabbit Polyclonal anti-WDR26 antibody (ABIN7870693) specifically detects WDR26 in WB, FACS, ELISA, ICC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for WDR26 antibody (AA 142-583) (ABIN7870693)

Target: WDR26 (WD Repeat Domain 26 (WDR26))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR26 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-WDR26 Antibody

Binding Specificity: AA 142-583

Purpose: WDR26 Antibody / WD repeat domain-containing protein 26

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human WDR26 recombinant protein (Position: Q142-E583) was used as the immunogen for the WDR26 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the WDR26 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the WDR26 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for WDR26

Target: WDR26 (WD Repeat Domain 26 (WDR26))

Alternative Name: WDR26

Background: WDR26 antibody detects WD repeat domain-containing protein 26, a multifunctional adaptor protein that participates in G protein-coupled receptor (GPCR) signaling, cytoskeletal regulation, and cell proliferation. Encoded by the WDR26 gene on chromosome 1q42.11, this protein contains several WD40 repeats that form a beta-propeller structure facilitating protein-protein interactions. WDR26 functions as a scaffold that coordinates signal transduction and cytoskeletal rearrangements downstream of heterotrimeric G proteins and growth factor receptors.

WDR26 localizes to both the cytoplasm and plasma membrane, where it binds Gbetagamma subunits and regulates downstream effectors such as PI3K, AKT, and ERK. By modulating these pathways, it controls cell migration, survival, and proliferation. Additionally, WDR26 plays roles in vesicle trafficking, stress response, and cell morphology through interactions with actin-associated proteins.

The WDR26 antibody is used in signaling, oncology, and molecular biology research to investigate scaffolding functions and GPCR-mediated pathways. Western blot analysis identifies a 65 kilodalton band corresponding to WDR26, while immunofluorescence shows cytoplasmic and membrane-associated staining. This antibody supports the study of protein complexes that regulate cellular communication and structure.

Aberrant expression of WDR26 has been linked to cancer progression and inflammatory signaling. Elevated WDR26 enhances AKT phosphorylation and cell survival, contributing to chemoresistance and metastasis, while loss of expression disrupts signaling coordination. The WDR26 antibody provides a valuable tool for exploring these mechanisms in disease and cellular physiology. NSJ Bioreagents validates this antibody for its applications, ensuring reliable performance in GPCR and signal transduction studies.

UniProt: Q9H7D7