GREM1 antibody (AA 147-175)

Catalog No. ABIN7870738

The Rabbit Polyclonal anti-GREM1 antibody (ABIN7870738) specifically detects GREM1 in WB and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for GREM1 antibody (AA 147-175) (ABIN7870738)

Target: GREM1 (Gremlin 1 (GREM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GREM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GREM1 Antibody

Binding Specificity: AA 147-175

Purpose: GREM1 Antibody / Gremlin 1

Purification: Antigen affinity

Immunogen: A portion of amino acids 147-175 from the human protein was used as the immunogen for the GREM1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the GREM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GREM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Alternative Name: GREM1

Background: GREM1, also referred to as Gremlin 1, is a protein that plays a crucial role in a variety of biological processes, ranging from embryonic development to cancer progression. This multifunctional protein is a member of the BMP (Bone Morphogenetic Protein) antagonist family and is known for its ability to regulate cell growth, differentiation, and survival. One of the most intriguing aspects of GREM1 is its role in embryonic development. Studies have shown that this protein is essential for proper development of various tissues and organs, such as the lung, kidney, and limb. Additionally, GREM1 has been implicated in the formation of certain structures in the developing embryo, highlighting its importance in shaping the body's overall architecture. In addition to its role in embryonic development, GREM1 has also been linked to various diseases, particularly cancer. Research has shown that abnormal levels of Gremlin 1 are associated with tumor growth, invasion, and metastasis in several types of cancer, including colorectal, ovarian, and pancreatic cancer. This suggests that targeting GREM1 could potentially be a novel strategy for combating cancer progression. GREM1 has recently gained attention for its potential as a therapeutic target in certain diseases.

UniProt: O70326

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location