LONP1 antibody (AA 148-334)

Catalog No. ABIN7870769

This Rabbit Polyclonal antibody specifically detects LONP1 in IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for LONP1 antibody (AA 148-334) (ABIN7870769)

Target: LONP1 (Lon Peptidase 1, Mitochondrial (LONP1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LONP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LONP1 Antibody

Binding Specificity: AA 148-334

Purpose: Zebrafish Lonp1 Antibody / Lon protease homolog

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Lonp1 recombinant protein (amino acids I148-A334) was used as the immunogen for the Zebrafish Lonp1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Lonp1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Lonp1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LONP1

Target: LONP1 (Lon Peptidase 1, Mitochondrial (LONP1))

Alternative Name: Lonp1

Background: Lon protease homolog, mitochondrial is an enzyme that in humans is encoded by the LONP1 gene. It is mapped to 19p13.3. This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia.