Transgelin antibody (AA 15-170)

Catalog No. ABIN7870782

The Rabbit Polyclonal anti-Transgelin antibody is suitable to detect Transgelin in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, FACS, IHC (p) and IF.

Quick Overview for Transgelin antibody (AA 15-170) (ABIN7870782)

Target: Transgelin (TAGLN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transgelin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Transgelin Antibody

Binding Specificity: AA 15-170

Purpose: TAGLN Antibody / Transgelin / SM22 alpha

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q15-E170) was used at the immunogen for the TAGLN antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TAGLN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TAGLN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Transgelin

Target: Transgelin (TAGLN)

Alternative Name: TAGLN

Background: Transgelin, also known as SM22 alpha, is a protein that in humans is encoded by the TAGLN gene. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

UniProt: Q01995