Aryl Hydrocarbon Receptor antibody (AA 15-196)

Catalog No. ABIN7870783

The Rabbit Polyclonal anti-Aryl Hydrocarbon Receptor antibody (ABIN7870783) specifically detects Aryl Hydrocarbon Receptor in WB, ELISA and FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Aryl Hydrocarbon Receptor antibody (AA 15-196) (ABIN7870783)

Target: Aryl Hydrocarbon Receptor (AHR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aryl Hydrocarbon Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Aryl Hydrocarbon Receptor Antibody

Binding Specificity: AA 15-196

Purpose: Ah Receptor Antibody / Aryl hydrocarbon Receptor

Purification: Affinity purified

Immunogen: Recombinant rat protein (amino acids R15-Q196) was used as the immunogen for the Ah Receptor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Ah Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Ah Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Aryl Hydrocarbon Receptor

Target: Aryl Hydrocarbon Receptor (AHR)

Alternative Name: Ah Receptor

Background: AHR (aryl hydrocarbon receptor), also called bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. AHR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The AHR gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr-/- or Er-alpha -/- ovariectomized mice. Complex assembly and ubiquitin ligase activity of CUL4B(AHR) in vitro and in vivo are dependent on the AHR ligand. In the CUL4B(AHR) complex, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Cd4-positive cells from mice lacking Ahr developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development. Activation of Ahr during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in Ahr-/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Ahr activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

UniProt: P41738

Pathways: Regulation of Cell Size