XIAP antibody (AA 15-244)

Catalog No. ABIN7870786

The Mouse Monoclonal anti-XIAP antibody (Clone 3G2G1) (ABIN7870786) specifically detects XIAP in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for XIAP antibody (AA 15-244) (ABIN7870786)

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This XIAP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3G2G1

Product Details anti-XIAP Antibody

Binding Specificity: AA 15-244

Purpose: XIAP Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A15-V244) was used as the immunogen for the XIAP antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the XIAP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the XIAP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Alternative Name: XIAP

Background: XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.

UniProt: P98170

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis