Recombinant PAX8 antibody (AA 150-300)

Catalog No. ABIN7870914

The Rabbit Monoclonal anti-PAX8 antibody is suitable to detect PAX8 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant PAX8 antibody (AA 150-300) (ABIN7870914)

Target: PAX8 (Paired Box 8 (PAX8))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PAX8 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: PAX8-6848R

Product Details anti-PAX8 Antibody

Binding Specificity: AA 150-300

Purpose: Paired box protein Pax-8 Antibody / PAX8 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 150-300) from the human protein was used as the immunogen for the Paired box protein Pax-8 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Paired box protein Pax-8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Paired box protein Pax-8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PAX8

Target: PAX8 (Paired Box 8 (PAX8))

Alternative Name: Paired box protein Pax-8

Background: Recognizes a protein of 62 kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

UniProt: Q06710

Pathways: Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation