GBX2 antibody (AA 150-350)

Catalog No. ABIN7870925

This Mouse Monoclonal antibody specifically detects GBX2 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for GBX2 antibody (AA 150-350) (ABIN7870925)

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GBX2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GBX2-7235

Product Details anti-GBX2 Antibody

Binding Specificity: AA 150-350

Purpose: GBX2 Antibody / Gastrulation Brain Homeobox 2

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 150-350) from the human protein was used as the immunogen for the GBX2 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the GBX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GBX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GBX2

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Alternative Name: GBX2

Background: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis, GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

UniProt: P52951

Pathways: Dopaminergic Neurogenesis