GLMN antibody (AA 153-574)

Catalog No. ABIN7870988

This Rabbit Polyclonal antibody specifically detects GLMN in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GLMN antibody (AA 153-574) (ABIN7870988)

Target: GLMN (Glomulin, FKBP Associated Protein (GLMN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLMN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-GLMN Antibody

Binding Specificity: AA 153-574

Purpose: GLMN Antibody / Glomulin

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GLMN recombinant protein (Position: Q153-R574) was used as the immunogen for the GLMN antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GLMN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GLMN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GLMN

Target: GLMN (Glomulin, FKBP Associated Protein (GLMN))

Alternative Name: GLMN

Background: GLMN antibody detects Glomulin, a cytoplasmic protein involved in ubiquitin-mediated protein degradation, vascular development, and smooth muscle cell regulation. Encoded by the GLMN gene on chromosome 1p22.1, this protein functions as an essential component of the E3 ubiquitin ligase complex that controls the turnover of signaling proteins in vascular and developmental pathways. GLMN acts as a suppressor of angiogenic signaling and maintains vascular integrity by promoting proper endothelial and smooth muscle interactions.

Glomulin interacts with Cullin-RING ligases and the SKP1-CUL1-F-box (SCF) complex, regulating substrate ubiquitination and degradation. By controlling ubiquitin homeostasis, it helps maintain cellular proteostasis and vessel wall stability. GLMN localizes to the cytoplasm and perinuclear regions, consistent with its role in ubiquitin regulation and protein quality control.

The GLMN antibody is used in vascular biology, developmental, and protein degradation research to investigate ubiquitination processes, angiogenesis, and smooth muscle differentiation. Western blot analysis identifies a 68 kilodalton band corresponding to Glomulin, while immunofluorescence shows cytoplasmic and perinuclear localization in endothelial and fibroblast cells. This antibody supports the study of vascular signaling and ubiquitin regulation mechanisms.

Mutations in GLMN cause glomuvenous malformations (glomangiomas), benign vascular lesions characterized by aberrant smooth muscle proliferation due to disrupted ubiquitin signaling. GLMN also participates in cell cycle regulation and differentiation, linking protein degradation to tissue morphogenesis. The GLMN antibody provides a robust reagent for studying ubiquitin-related vascular disorders and developmental signaling. NSJ Bioreagents validates this antibody for its applications, ensuring high specificity and reproducibility for vascular and ubiquitin pathway research.

UniProt: Q92990

Pathways: Tube Formation